Senior lecturer at the University of the Free State’s (UFS) Medical Science Department, Dr Matlakala Claudia Ntsapi, is leading a fight against neurodegenerative diseases, like Alzheimer’s disease, by researching the potential of medicinal plants.
Dr Ntsapi was inspired to pursue this field during her Master of Medical Science studies, where her research included new genetic mutations in patients affected by Parkinson’s disease.
“This research aimed to expand our understanding of unique genetic contributions in the South African patient population, to contribute towards the development of personalised treatments,” she explained.
“I became increasingly interested in enhancing my experimental laboratory skills and understanding the biological processes involved in another age-related brain disease, such as Alzheimer’s disease.”
Dr Ntsapi’s interest in developing cell-based models that mimic these diseases allows her to explore the factors that contribute to neurodegenerative diseases, as well as develop effective treatments that enhance the quality of life for those affected.
Speaking on the importance of her research, Ntsapi said: “According to recent statistics on the global burden of diseases, neurodegenerative diseases are among the leading causes of death worldwide, particularly as the proportion of ageing populations continues to increase.”
She also added: “Every year, an estimated 6.9 million people die because of these diseases. Research into neurodegenerative diseases is therefore necessary, more so in African countries.”
Her decision to research the potential of medicinal plants is based on the trust placed on these resources in an African context, as well as the issue of insufficient drug supplies, the high cost of modern medicines, as well as the adverse effects these synthetic treatments may have.
“In many parts of South Africa, modern medical facilities are scarce, making traditional medicine an essential alternative,” she said.
Ntsapi went on to explain that “South Africa is home to a rich diversity of plant species with potential medicinal properties. With about 24,000 documented plant species, South Africa is home to nearly 10% of the world’s plant species, but only a small percentage have been studied for their medicinal characteristics. This vast untapped resource offers immense potential for discovering new therapeutic compounds.”
While finding a cure for neurodegenerative diseases remains a significant clinical and research challenge, Dr Ntsapi believes that there are several reasons to be optimistic.
She also hopes to have a long academic career and aide the fight against Alzheimer’s disease.
Warren Hawkins
